It may be worth pointing out
that the commonest reason for stopping this leukotriene
antagonist is ineffectiveness.It is safe, except that there is a continuing discussion
whether it can convert one kind of inflammatory response into another
more vasculitic (Churg Strauss).Reminding me of a long term discussion whether suppressing
neutrophil mechanisms to eliminate immune complexes or bacteria
results in slower elimination of noxious agents which is their job.It dates from the early days
of prescribing steroids for Henoch Schoenlein purpura and whether it
protected the kidney or not.I
would make certain of close follow up of any kind of immune
complex disease.
Here is the Pub Med item
for example which says its safe but not very effective.Mostly used for asthma but
also Rheumatoid arthritis and inflammatory bowel disease.Dermatologists use it for
Urticaria without much success.
