Leprosy Mailing List – September 7th, 2007
Ref.:
Alternative treatment regimens to standard
W.H.O. multidrug therapy (MDT)
From: Periche Fernandez J. D., Santo Domingo,
Dominican Republic
Dear Salvatore,
I would like to request advise about
alternative treatment regimens to MDT.
I have two patients, here in the Dominican Republic who do not
tolerate dapsone.
The first one is a young female with tuberculoid
leprosy. She develops
metahaemoglobinenemia, I think, her lips, fingers and toes become
purple as soon as she takes dapsone. The second one is a
multibacillary (MB) leprosy case who suffers from hepatitis C and her
gastroenterologist did not allowed the use of rifampin or dapsone.
I think both could be treated with rifampicin, ofloxacine and
minocicline (ROM) but there is not minocicline available in this
country.
I would be grateful to receive advises on what could be done in such
cases?
Best regards,
Dr. Juan Periche Fernandez
Medico-Dermatologo
Director Unidad de Lepra del Distrito Nacional
Coordinador Comite de etica interno (Internal review board)
Instituto Dermatologico y Cirugia de Piel
Dr Huberto Bogaert Diaz (IDCP-Dr.HBD)
office (809) 684-3257 ext 234
Fax (809) 681-7687
Apartado postal 1090
Corazones Unidos
Dermatologia y Cosmiatria
(809) 683-6185
mobile (809)815-1060
e mail jperiche@hvtudr.org
Santo Domingo DN Rep Dominicana
