Leprosy
Mailing List – February 2nd,
2010
Ref.: Leprosy
patients developing erythema nodosum leprosum (ENL) reactions after
stopping multi-drug therapy (MDT)
From:
Wim
H. van Brakel,
Amsterdam
,
Netherlands
Dear
Prof. Das,
I
refer to your message dated LML Jan. 23rd, 2010 regarding
leprosy patients developing ENL reactions after stopping MDT.
I
am very sure about this observation, but realise that this does not
constitute 'evidence' in itself. I
have tried to encourage people in many countries to collect such
information systematically. Unfortunately
I do not know of a single (published) study with adequate design that
has done this. There was
one paper from the
Philippines
presented at the last World Leprosy Congress that was a good attempt,
but they had used a non-concurrent control group in a comparison study
of prolonged clofazimine treatment vs no clofazimine. I'd
be interested in any other data readers may have or know on this.
With
kind regards,
Wim
van Brakel
Wim
H. van Brakel
Royal
Tropical Institute
Leprosy Unit
and
Athena
Institute
Faculty
of Earth and Life Sciences
VU
University
Correspondence
address:
Wibautstraat
137k
1097DN
Amsterdam
Netherlands
tel +3120 6939297
fax
+3120 6680823
w.v.brakel(at)kit.nl
wim.van.brakel(at)falw.vu.nl
