Leprosy
Mailing List – May 10th , 2010
Ref.: Feeding
25 mg dose of clofazimine daily to a 2 year baby
From: H K Kar,
New Delhi
,
India
Dear
Dr Saba,
I
refer to your message dated May 9th, 2010. Your
problem of feeding 25 mg dose of clofazimine daily to a 2 year baby is
a genuine concern due to non availability of 25mg capsule as well
as liquid preparation. The drug is not water-soluble, hence micronised
crystals are suspended in an oil-max base and encapsulated in soft
gelatin for oral administration. The
absorption in this form is even only 30% to 50%.
As
suggested by other LML members, you can feed 50 mg weekly twice.
The soft gelatine capsule can be punctured and the oil-wax based clofazimine
can be expressed from the capsule into a half teaspoon full of
honey which can easily be fed to the baby twice a week, same way the
monthly pulse dose also.
Regards,
Dr
(Prof.) H K Kar
Consultant & HOD
Department of Dermatology, STD & Leprosy
P.G.I.M.E.R. and Dr Ram Manohar Lohia Hospital
Baba Kharag Singh Marg
New Delhi-110001
