Leprosy
Mailing List – August 29th, 2010
Ref.: Can
drug used in leprosy (Clofazimine, Dapsone, Rifampicin and
Prednisolone) cause hyponatraemia?
From:
Lysbeth
Duncan,
Peebles
,
Scotland
, UK
Dear
Dr. Noto,
I refer to Mr Adamou
Idi’s message dated LML Aug. 23rd, 2010.
Having used the four drugs listed without seeing any evidence
of hyponatraemia, personally I am not aware of this being a problem.
I do know that Rifampicin reduces the efficacy of prednisolone by 50%,
as can oral contraceptives. I shall forward this letter to a
colleague who is a leprologist and Microbiologist in case he can help
further.
Best
regards,
Lysbeth Duncan
*
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1547305/pdf/bmjcred00545-0011.pdf
Rifampicin
reduces effectiveness and bioavailability of prednisolone
w
a c mcallister, p j thompson, s m al-habet, h j
rogers
british
medical journal volume 286 19 march 1983
