Leprosy
Mailing List – August 29th, 2010
Ref.: Clofazimine
in ENL reaction
From:
Ailton
Santos Romero, Caruaru,
Pernambuco
,
Brazil
Dear
Dr. Noto
Drugs
currently used in the treatment of reactions in leprosy are:
non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and
thalidomide. Thalidomide is the treatment of choice in erythema
nodosum leprosum (ENL) or type 2 reaction, except for women of child
bearing age.
In
our centre, prednisolone and thalidomide, in men only, are the drugs
of choice in ENL. In the
past in patients with relapsing and chronic ENL reaction we have also
used a regimen containing clofazimine.
We found it useful in cases of steroid dependent ENL.
The doses of clofazimine that we used were:
300mg,
the first month
200mg the second month
100mg in the third month
50mg in treatment continued
until remission of the clinical picture.
Unfortunately
loose clofazimine is currently not available in our country.
I
would like asking the experience of colleagues about the use of such a
regimen, particularly about the time of regression of the reaction
using clofazimine. We had
excellent results with clofazimine, do others confirm this?
Thank you very much
in advance for your collaboration.
My sincere compliments,
Dr. Ailton
Santos
Romero
Reference
Regional
Medical
Center
Leprosy and AIDS -
Health
Department
City
of
Caruaru
Pernambuco
State
Brazil
Address:
Health
Center
, Amelia Bridges
Avenida Guararapes, S / N -
Centre
City
of
Caruaru
CEP 55000-000
Pernambuco
State
Brazil
